The league has ruled out a 'pause' to the season to allow clubs to recover their squads, although the surging Omicron variant has put paid to half of the weekend's fixtures including Manchester United's home game with Brighton & Hove Albion.
Leicester City said they had a request to postpone Thursday's game against Tottenham Hotspur rejected by the league.
Newcastle's worries deepened as they now remain at 19th in the table.
Chelsea paid a heavy price for a 3-2 defeat at West Ham United as first Liverpool, then Manchester City, leapfrogged them in the English Premier League title race on Saturday, with City ending the day on top for the first time this season.
Images from Saturday's action in the Premier League.
Imperious Liverpool extended their Premier League home winning streak against Arsenal to six on Saturday with an easy 4-0 victory that lifted them to second in the table.
A summary of Saturday's action in the Premier League.
Nuno's coaching staff have also been relieved of their duties. The club have not yet announced a replacement but British media reported former Chelsea and Inter Milan boss Antonio Conte is linked.
Images from the English Premier League matches played on Saturday.
Images from Saturday's Premier League matches.
Equality and inclusion group Kick It Out are reportedly planning to offer education workshops in Newcastle to supporters to explain how impersonating Arabs could be considered be racist or culturally insensitive.
Ronaldo enjoyed a dream first appearance on his return to the club, scoring two goals in the 4-1 home victory over Newcastle United.
Images from the English Premier League matches played on Saturday.
Cristiano Ronaldo has been voted Manchester United's Player of the Month for September by the club's supporters.
Likens the Portuguese's second debut at United against Newcastle to Ceasar entering Rome.
The Portuguese star is set to earn $125 million before taxes in the 2021-22 season, with $70 million coming from salary and bonus after his return to United.
A summary of Sunday's action in the Premier League.
Friday's 1-1 draw left Newcastle 18th on two points and piled more pressure on manager Steve Bruce while Leeds are 16th on three points after they missed a string of chances in an action-packed first half.
'I was thinking last night that I wanted to show I'm still capable of helping the team. When I started the game, I was super nervous when they were singing my name but this crowd is unbelievable.'
IMAGES from Premier League matches played on Saturday.
CR7 started the game against the Toons in his second debut at Old Trafford.
As the Premier League resumes following the international break all eyes will be on Cristiano Ronaldo's homecoming party at Old Trafford on Saturday, with the Portuguese international set to resume his Manchester United career after 12 years away.
News of all that transpired on and off the football field
He donned the number seven shirt during his first stint at the club, following in the footsteps of great United players including George Best, Bryan Robson, Eric Cantona and David Beckham.
Cristiano Ronaldo broke the all-time international goalscoring record on Wednesday in a stunning late show for his side, with his 110th and 111th Portugal goals taking him past Iranian great Ali Daei's mark.
'History has been written in the past and history will be written once again! You have my word!'
'I cannot wait to play at Old Trafford in front of a full stadium and see all the fans again.'
With the league paused for the international break, Ronaldo is expected to play his first game when United host Newcastle United at old Trafford on September 11.
West Brom, relegated from the Premier League last season, made 11 changes from the side that won at the weekend in the Championship and had five players -- including goalkeeper Alex Palmer -- making their debuts.
Norwich opened the floodgates in one of three earlier kickoffs, with their new U.S. international signing Josh Sargent and Greek winger Christos Tzolis each scoring twice on their full debuts at Carrow Road.
IMAGES from the Premier League matches played on Sunday.
Images from the English Premier League matches on Saturday.
Among other transfer news globally, defender Rahul Bheke joins Mumbai City FC while Locatelli completes Juventus move.
Images from Sunday's action in the Premier League.
UEFA said Eriksen, who was given CPR by medics on the pitch, was transferred to hospital where the 29-year-old was stabilised, with officials saying he was conscious. Following is a list of players who have collapsed on the pitch during a match.
Scotland's Clarke names uncapped trio in Euro squad.
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
City having already bagged the title and Newcastle safe, there was nothing riding on the fixture but it served up some rich entertainment
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Images from the English Premier League matches played on Saturday.
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